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Drug Name Vantictumab
Trade Name
Synonyms anti-Fzd7|OMP-18R5
Drug Descriptions

Vantictumab (OMP-18R5) is a monoclonal antibody that targets Frizzled receptors 1, 2, 5, 7, and 8, resulting in decreased Wnt signaling and potentially leading to decreased tumor growth (PMID: 22753465, PMID: 31338636).

DrugClasses WNT Inhibitor 15
CAS Registry Number 1345009-45-1
NCIT ID C96799

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Docetaxel + Vantictumab Docetaxel Vantictumab 0 1
Gemcitabine + Nab-paclitaxel + Vantictumab Gemcitabine Nab-paclitaxel Vantictumab 0 1
Gemcitabine + Vantictumab Gemcitabine Vantictumab 0 0
Paclitaxel + Vantictumab Paclitaxel Vantictumab 0 1
Vantictumab Vantictumab 1 0


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