Drug Detail


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Drug Name MK-7684
Trade Name
Synonyms MK7684|MK 7684|Vibostolimab
Drug Descriptions

MK-7684 (Vibostolimab) is antagonistic against against T-cell immunoreceptor with Ig and ITIM domains (TIGIT), which removes the immune checkpoint blockade by preventing the interaction of TIGIT with its ligands, NECTIN2 (CD112) and PVR (CD155) (NCI Drug Dictionary).

DrugClasses Immune Checkpoint Inhibitor 135
CAS Registry Number 2231305-30-7
NCIT ID C140041


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carboplatin + MK-7684 + Paclitaxel + Pembrolizumab Carboplatin MK-7684 Paclitaxel Pembrolizumab 0 1
Carboplatin + MK-7684 + Pembrolizumab + Pemetrexed Disodium Carboplatin MK-7684 Pembrolizumab Pemetrexed Disodium 0 1
MK-1308 + MK-7684 + Pembrolizumab MK-1308 MK-7684 Pembrolizumab 0 1
MK-7684 MK-7684 0 2
MK-7684 + Pembrolizumab MK-7684 Pembrolizumab 0 3

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