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Drug Name MK-7684
Trade Name
Synonyms
Drug Descriptions

MK-7684 is antagonistic against against T-cell immunoreceptor with Ig and ITIM domains (TIGIT), which removes the immune checkpoint blockade by preventing the interaction of TIGIT with its ligands, NECTIN2 (CD112) and PVR (CD155) (NCI Drug Dictionary).

DrugClasses Immune Checkpoint Inhibitor 94

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carboplatin + MK-7684 + Paclitaxel + Pembrolizumab Carboplatin MK-7684 Paclitaxel Pembrolizumab 0 1
Carboplatin + MK-7684 + Pembrolizumab + Pemetrexed Disodium Carboplatin MK-7684 Pembrolizumab Pemetrexed Disodium 0 1
MK-1308 + MK-7684 + Pembrolizumab MK-1308 MK-7684 Pembrolizumab 0 1
MK-7684 MK-7684 0 1
MK-7684 + Pembrolizumab MK-7684 Pembrolizumab 0 3


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