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|Drug Name||HPVST cells|
|Synonyms||Autologous HPV-16/18 E6/E7-specific TGF-beta-resistant T Lymphocytes|
HPVST cells are autologous T cells that are stimulated with HPV-16/18-loaded dendritic cells and are also engineered to express a dominant-negative TGF-beta receptor II that inhibits TGF-beta signaling, which potentially results in increased T cell response against HPV-16/18-positive tumor cells (NCI Drug Dictionary).
|CAS Registry Number||NA|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Cyclophosphamide + Fludarabine + HPVST cells + Nivolumab||Cyclophosphamide Fludarabine HPVST cells Nivolumab||0||1|
|HPVST cells||HPVST cells||0||1|