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Drug Name TG-1801
Trade Name
Synonyms NI-1701|TG1801|TG 1801
Drug Descriptions

TG-1801 (NI-1701) is a bispecific antibody to CD47 and CD19 designed to selectively engage malignant B-cells (PMID: 29743205) and block CD47 downstream signaling and subsequent activation of the SIRPa receptor on macrophages, leading to phagocytosis of tumor cells (PMID: 28286286) and may also stimulate cytotoxic T-cells (PMID: 29873856).

DrugClasses CD19 Antibody 12 CD47 Antibody 16 Immune Checkpoint Inhibitor 135
CAS Registry Number NA
NCIT ID C166137

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Therapy Name Drugs Efficacy Evidence Clinical Trials
TG-1801 TG-1801 0 1
TG-1801 + Ublituximab TG-1801 Ublituximab 0 1


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