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Drug Name Anti-NY ESO-1 mTCR PBL
Trade Name
Synonyms NY-ESO-1 reactive TCR retroviral vector transduced autologous PBL
Drug Descriptions

Anti-NY ESO-1 mTCR PBL are peripheral blood lymphocytes that have been transduced with a retroviral vector expressing a T-cell receptor that targets NY-ESO, which may enhance anti-tumor immune response against NY-ESO-expressing tumor cells (PMID: 24598449).

DrugClasses

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Aldesleukin + Anti-NY ESO-1 mTCR PBL + Cyclophosphamide + Fludarabine Aldesleukin Anti-NY ESO-1 mTCR PBL Cyclophosphamide Fludarabine 0 1
Aldesleukin + Anti-NY ESO-1 mTCR PBL + Cyclophosphamide + Fludarabine + NY-ESO-1 peptide vaccine Aldesleukin Anti-NY ESO-1 mTCR PBL Cyclophosphamide Fludarabine NY-ESO-1 peptide vaccine 0 1
Anti-NY ESO-1 mTCR PBL Anti-NY ESO-1 mTCR PBL 0 0
Anti-NY ESO-1 mTCR PBL + Cyclophosphamide + TGFbDNRII-transduced autologous TILs Anti-NY ESO-1 mTCR PBL Cyclophosphamide TGFbDNRII-transduced autologous TILs 0 1


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