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Drug Name ROR1 CAR-T cells
Trade Name
Synonyms autologous ROR1-CAR-T cells
Drug Descriptions

ROR1 CAR-T cells are autologous T-lymphocytes engineered to express anti-ROR1 single-chain variable fragment linked to CD28 transmembrane domain, and either 4-1BB/CD3zeta or CD28/CD3zeta signaling domains, which potentially induces immune response against ROR1-expressing tumor cells, leading to apoptosis and tumor cell lysis (PMID: 31415244).

DrugClasses

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cyclophosphamide + Fludarabine + ROR1 CAR-T cells Cyclophosphamide Fludarabine ROR1 CAR-T cells 0 1
ROR1 CAR-T cells ROR1 CAR-T cells 0 0


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