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|Drug Name||ROR1 CAR-T cells|
|Synonyms||autologous ROR1-CAR-T cells|
ROR1 CAR-T cells are autologous T-lymphocytes engineered to express anti-ROR1 single-chain variable fragment linked to CD28 transmembrane domain, and either 4-1BB/CD3zeta or CD28/CD3zeta signaling domains, which potentially induces immune response against ROR1-expressing tumor cells, leading to apoptosis and tumor cell lysis (PMID: 31415244).
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Cyclophosphamide + Fludarabine + ROR1 CAR-T cells||Cyclophosphamide Fludarabine ROR1 CAR-T cells||0||1|
|ROR1 CAR-T cells||ROR1 CAR-T cells||0||0|