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Drug Name CD19-CD8-CD28-CD3zeta-CAR-mbIL15-HER1t T cells
Trade Name
Synonyms
Drug Descriptions

Autologous CD19-CD8-CD28-CD3zeta-CAR-mbIL15-HER1t T cells are engineered T cells expressing chimeric antigen receptor consisted of CD19 linked to CD8, CD28, and TCR/CD3-zeta, a co-expressing membrane-bound IL-15 and IL-15 receptor fusion protein (mbIL15), and a truncated EGFR (HER1t), which may lead to cytotoxic immune response against CD19-expressing tumor cells (NCI Drug Dictionary).

DrugClasses

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Therapy Name Drugs Efficacy Evidence Clinical Trials
CD19-CD8-CD28-CD3zeta-CAR-mbIL15-HER1t T cells CD19-CD8-CD28-CD3zeta-CAR-mbIL15-HER1t T cells 0 0
CD19-CD8-CD28-CD3zeta-CAR-mbIL15-HER1t T cells + Cyclophosphamide + Fludarabine CD19-CD8-CD28-CD3zeta-CAR-mbIL15-HER1t T cells Cyclophosphamide Fludarabine 0 1


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