Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Synonyms||gemcitabine ProTide|Fosgemcitabine Palabenamide|NUC 1031|Acelarin|
NUC-1031 is a gemicitabine-derivative pyrimidine analogue prodrug that is converted into the products dFdCDP and dFdCTP, which reduce the nucleotide pool for DNA replication and inhibit DNA synthesis, respectively, potentially resulting in increased tumor cell apoptosis (PMID: 30206366, PMID: 31113993).
|DrugClasses||Chemotherapy - Antimetabolite 11|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Cisplatin + NUC-1031||Cisplatin NUC-1031||0||1|