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Drug Name NUC-1031
Trade Name
Synonyms gemcitabine ProTide|Fosgemcitabine Palabenamide|NUC 1031|Acelarin
Drug Descriptions

NUC-1031 is a gemicitabine-derivative pyrimidine analogue prodrug that is converted into the products dFdCDP and dFdCTP, which reduce the nucleotide pool for DNA replication and inhibit DNA synthesis, respectively, potentially resulting in increased tumor cell apoptosis (PMID: 30206366, PMID: 31113993).

DrugClasses Chemotherapy - Antimetabolite 14
CAS Registry Number 840506-29-8
NCIT ID C102752


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cisplatin + NUC-1031 Cisplatin NUC-1031 0 1
NUC-1031 NUC-1031 0 0

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