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|Drug Name||Oncolytic HSV-1 rRp450|
Oncolytic HSV-1 rRp450 is an engineered oncolytic type-I herpes simplex virus 1 (HSV-1) that encodes CYP2B1, which activates cancer prodrugs including cyclophosphamide and enhances sensitivity to chemotherapy agents, potentially resulting in increased tumor cell lysis and reduced metastases (PMID: 12209705).
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Cyclophosphamide + Oncolytic HSV-1 rRp450||Cyclophosphamide Oncolytic HSV-1 rRp450||1||0|
|Oncolytic HSV-1 rRp450||Oncolytic HSV-1 rRp450||1||1|