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Drug Name Oncolytic HSV-1 rRp450
Trade Name
Synonyms rRp450
Drug Descriptions

Oncolytic HSV-1 rRp450 is an engineered oncolytic type-I herpes simplex virus 1 (HSV-1) that encodes CYP2B1, which activates cancer prodrugs including cyclophosphamide and enhances sensitivity to chemotherapy agents, potentially resulting in increased tumor cell lysis and reduced metastases (PMID: 12209705).



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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cyclophosphamide + Oncolytic HSV-1 rRp450 Cyclophosphamide Oncolytic HSV-1 rRp450 1 0
Oncolytic HSV-1 rRp450 Oncolytic HSV-1 rRp450 1 1

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