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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT04424966	Phase 0	Infigratinib	Infigratinib in Recurrent High-Grade Glioma Patients	Terminated	USA	0
NCT04565275	Phase Ib/II	ICP-192	A Study of ICP-192 in Patients With Advanced Solid Tumors	Recruiting	USA \| AUS	0
NCT04045613	Phase Ib/II	Derazantinib Atezolizumab + Derazantinib	Derazantinib and Atezolizumab in Patients With Urothelial Cancer (FIDES-02)	Completed	USA \| ITA \| GBR \| FRA \| ESP \| DEU \| CAN \| AUT \| AUS	5
NCT04083976	Phase II	Erdafitinib	A Study of Erdafitinib in Participants With Advanced Solid Tumors and Fibroblast Growth Factor Receptor (FGFR) Gene Alterations (RAGNAR)	Active, not recruiting	USA \| ITA \| GBR \| FRA \| ESP \| DEU \| BEL \| AUS	7
NCT02846766	Phase II	Lenvatinib	Study of Lenvatinib in Patients With Advanced Cancer and Aberrations in FGF/FGFR Signaling	Withdrawn	USA	0
NCT02872714	Phase II	Pemigatinib	A Study to Evaluate the Efficacy and Safety of Pemigatinib (INCB054828) in Subjects With Urothelial Carcinoma - (FIGHT-201)	Completed	USA \| NLD \| ITA \| GBR \| FRA \| ESP \| DEU \| BEL	3
NCT03822117	Phase II	Pemigatinib	Efficacy and Safety of Pemigatinib in Previously Treated Locally Advanced/Metastatic or Surgically Unresectable Solid Tumor Malignancies Harboring Activating FGFR Mutations or Translocations (FIGHT-207)	Terminated	USA \| ITA \| GBR \| FRA \| ESP \| DEU	5
NCT01928459	Phase I	Alpelisib + Infigratinib	Phase 1b Trial of BGJ398/BYL719 in Solid Tumors	Completed	USA \| NLD \| ITA \| FRA \| ESP \| DEU \| CAN \| BEL \| AUS	3
NCT04088188	Phase I	Cisplatin + Gemcitabine + Pemigatinib Cisplatin + Gemcitabine + Ivosidenib	Gemcitabine and Cisplatin With Ivosidenib or Pemigatinib for the Treatment of Unresectable or Metastatic Cholangiocarcinoma	Active, not recruiting	USA	0
NCT02393248	Phase Ib/II	Cisplatin + Gemcitabine + Pemigatinib Docetaxel + Pemigatinib Pemigatinib + Retifanlimab Pemigatinib + Trastuzumab Epacadostat + Pembrolizumab	Open-Label, Dose-Escalation Study of Pemigatinib in Subjects With Advanced Malignancies - (FIGHT-101)	Terminated	USA	1
NCT02693535	Phase II	Cobimetinib + Vemurafenib Atezolizumab + Talazoparib Regorafenib Larotrectinib Trastuzumab + Tucatinib Ipilimumab + Nivolumab Palbociclib Afatinib Entrectinib Talazoparib Pembrolizumab Temsirolimus Pertuzumab + Trastuzumab Atezolizumab + Pertuzumab/trastuzumab/hyaluronidase-zzxf Crizotinib Abemaciclib Sunitinib Olaparib	TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer (TAPUR)	Recruiting	USA	0
NCT02747797	Phase II	Lucitanib	Lucitanib (E3810) in Patients With Advanced Cancer and FGFR, VEGFR, or PDGFR Pathway Aberrations	Withdrawn	USA	0
NCT03210714	Phase II	Erdafitinib	Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial)	Active, not recruiting	USA	1
NCT02312804	Phase I	Paclitaxel Carboplatin Infigratinib	Ph Ib/BGJ398/Cervix and Other Solid Tumors	Withdrawn		0
NCT04294277	Phase II	Pemigatinib	Safety and Efficacy of Pemigatinib in Patients With High-risk Urothelial Cancer After Radical Surgery (PEGASUS)	Terminated	ITA	0
NCT03934372	Phase Ib/II	Ponatinib	Safety and Efficacy of Ponatinib for Treatment of Pediatric Recurrent or Refractory Leukemias, Lymphomas or Solid Tumors	Recruiting	NLD \| ITA \| GBR \| FRA \| ESP \| DEU \| BEL	2
NCT04233567	Phase II	Infigratinib	Infigratinib for the Treatment of Advanced or Metastatic Solid Tumors in Patients With FGFR Gene Mutations	Active, not recruiting	USA	0
NCT01831726	Phase II	Dovitinib	Dovitinib for Patients With Tumor Pathway Activations Inhibited by Dovitinib	Completed	USA	0
NCT04003623	Phase II	Pemigatinib	Efficacy and Safety of Pemigatinib in Participants With Solid Tumors With FGFR Mutations or Translocations (FIGHT-208)	Terminated	USA	0
NCT02299141	Phase I	Nintedanib	Nintedanib in Molecularly Selected Patients With Advanced Non-Small Cell Lung Cancer	Active, not recruiting	USA	0
NCT04172675	Phase II	Erdafitinib Gemcitabine Mitomycin C	A Study of Erdafitinib Versus Investigator Choice of Intravesical Chemotherapy in Participants Who Received Bacillus Calmette-Guérin (BCG) and Recurred With High Risk Non-Muscle-Invasive Bladder Cancer (NMIBC)	Active, not recruiting	USA \| ITA \| GBR \| FRA \| ESP \| DEU \| BEL \| AUS	9
NCT02160041	Phase II	Infigratinib	BGJ398 for Patients With Tumors With FGFR Genetic Alterations	Terminated	USA	0
NCT02706691	Phase II	Infigratinib	Pan FGFR Kinase Inhibitor BGJ398 in Treating Patients With FGFR1-3 Translocated, Mutated, or Amplified Recurrent Head and Neck Cancer	Terminated	USA	0
NCT04463771	Phase II	Pemigatinib + Retifanlimab Epacadostat + Retifanlimab Retifanlimab	Safety and Efficacy of Retifanlimab (INCMGA00012) Alone or in Combination With Other Therapies in Participants With Advanced or Metastatic Endometrial Cancer Who Have Progressed on or After Platinum-based Chemotherapy. (POD1UM-204)	Recruiting	USA \| ITA \| FRA \| DEU \| BEL	3
NCT01948297	Phase I	Debio 1347	Debio 1347-101 Phase I Trial in Advanced Solid Tumours With Fibroblast Growth Factor Receptor (FGFR) Alterations	Terminated	USA \| ESP	3
NCT03297606	Phase II	Bosutinib Palbociclib Vismodegib Ipilimumab + Nivolumab Cobimetinib + Vemurafenib Temsirolimus Olaparib Erlotinib Crizotinib Sunitinib Afatinib Dasatinib Pertuzumab + Trastuzumab Axitinib	Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR) (CAPTUR)	Recruiting	CAN	0
NCT04504331	Phase I	Fulvestrant + Infigratinib + Palbociclib Infigratinib + Tamoxifen	Study of Infigratinib in Combination With Tamoxifen or With Fulvestrant and Palbociclib in Hormone Receptor Positive, HER2 Negative, FGFR Altered Advanced Breast Cancer	Terminated	USA	0
NCT05216120	Phase II	Pemigatinib	Pemigatinib in Subjects With Adenosquamous Carcinoma of the Pancreas	Withdrawn	USA	0
NCT03801434	Phase II	Ruxolitinib	Ruxolitinib in Treating Patients With Hypereosinophilic Syndrome or Primary Eosinophilic Disorders	Recruiting	USA	0
NCT03155620	Phase II	Tazemetostat Larotrectinib LY3023414 Vemurafenib Palbociclib Olaparib Ulixertinib Erdafitinib Selumetinib Ensartinib	Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)	Recruiting	USA \| CAN \| AUS	1
NCT02558348	Phase Ib/II	Anlotinib	Phase 1/2a Evaluation of AL3818 in Subjects With Recurrent or Metastatic Endometrial, Ovarian or Cervical Cancer (AL3818-US-001)	Terminated	USA	0
NCT04604132	Phase Ib/II	Atezolizumab + Derazantinib Derazantinib + Paclitaxel + Ramucirumab Derazantinib Paclitaxel + Ramucirumab	Derazantinib Alone or in Combination With Paclitaxel, Ramucirumab or Atezolizumab in Gastric Adenocarcinoma (FIDES-03)	Terminated	USA \| ITA \| GBR \| FRA \| ESP \| DEU \| BEL \| AUS	7
NCT02608125	Phase I	PRN1371	A Dose Escalation Study in Solid Tumors and a Dose Expansion Study of PRN1371 in Adult Patients With Metastatic Urothelial Carcinoma	Terminated	USA \| ESP	0
NCT06160752	Phase I	TYRA-200	Safety and Anti-Tumor Activity of TYRA-200 in Advanced Cholangiocarcinoma With Activating FGFR2 Gene Alterations (SURF201)	Recruiting	USA	0
NCT04595747	Phase II	Rogaratinib	Testing the Anti-cancer Drug, Rogaratinib (BAY 1163877), for Treatment of Advanced Sarcoma With Alteration in Fibroblast Growth Factor Receptor (FGFR 1-4), and in Patients With SDH-deficient Gastrointestinal Stromal Tumor (GIST)	Active, not recruiting	USA	0
NCT05267106	Phase II	Pemigatinib	Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Previously Treated Glioblastoma or Other Primary Central Nervous System Tumors Harboring Activating FGFR1-3 Alterations (FIGHT-209)	Active, not recruiting	USA \| NLD \| ITA \| GBR \| FRA \| ESP \| DEU	2
NCT02052778	Phase Ib/II	Futibatinib	A Study of TAS-120 in Patients With Advanced Solid Tumors	Completed	USA \| NLD \| ITA \| GBR \| FRA \| ESP \| DEU \| CAN \| AUS	4
NCT02272998	Phase II	Ponatinib	Ponatinib for Patients Whose Advanced Solid Tumor Cancer Has Activating Mutations Involving the Following Genes: FGFR1, FGFR2, FGFR3, FGFR4, RET, KIT.	Active, not recruiting	USA	0
NCT05316155	Phase I	Erdafitinib	Study of Erdafitinib Intravesical Delivery System for Localized Bladder Cancer	Recruiting	USA \| NLD \| ESP \| DEU	1
NCT01975701	Phase II	Infigratinib	A Phase 2 Study of BGJ398 in Patients With Recurrent GBM	Completed	USA \| NLD \| ESP \| BEL \| AUS	1
NCT02925234	Phase II	Palbociclib Ribociclib Lenvatinib Ipilimumab + Nivolumab Trametinib Crizotinib Niraparib Selpercatinib Olaparib Erlotinib Erdafitinib Dabrafenib Dacomitinib Rucaparib Axitinib Panitumumab Pemigatinib Durvalumab Afatinib Entrectinib Tepotinib Alpelisib Atezolizumab + Bevacizumab Alectinib Regorafenib Cobimetinib + Vemurafenib Nilotinib Vismodegib Abemaciclib Sunitinib Nivolumab Cabozantinib Lorlatinib Talazoparib Dabrafenib + Trametinib Pembrolizumab Pertuzumab + Trastuzumab	The Drug Rediscovery Protocol (DRUP Trial) (DRUP)	Recruiting	NLD	0
NCT05253807	Phase II	Pemigatinib	Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Relapsed or Refractory Advanced Non-Small Cell Lung Cancer With an FGFR Alteration (FIGHT-210)	Completed	USA \| ITA \| FRA \| ESP \| DEU	0
NCT04923126	Phase Ib/II	PD-0325901	SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma	Recruiting	USA	0
NCT04096417	Phase II	Pemigatinib	Pemigatinib for the Treatment of Metastatic or Unresectable Colorectal Cancer Harboring FGFR Alterations	Active, not recruiting	USA	0
NCT06302621	Phase I	Afatinib + Pemigatinib	Pemigatinib + Afatinib in Advanced Refractory Solid Tumors	Not yet recruiting	USA	0
NCT05627063	Phase I	ABSK121	A Study to Assess Safety, Tolerability, and Pharmacokinetics of ABSK121-NX in Patients With Advanced Solid Tumors	Recruiting	USA	1
NCT03827850	Phase II	Erdafitinib	FGFR Inhibitor in FGFR Dysregulated Cancer (FIND)	Terminated	DEU	0
NCT04483505	Phase I	Fulvestrant + Palbociclib + Rogaratinib	Rogaratinib, Palbociclib y Fulvestrant in Patients With Breast Cancer. (ROGABREAST)	Completed	ESP	0
NCT03410693	Phase II	Docetaxel Vinflunine Paclitaxel Rogaratinib	Study of Rogaratinib (BAY1163877) vs Chemotherapy in Patients With FGFR (Fibroblast Growth Factor Receptor)-Positive Locally Advanced or Metastatic Urothelial Carcinoma (FORT-1)	Completed	USA \| NLD \| ITA \| GBR \| FRA \| ESP \| DEU \| CAN \| BEL \| AUT \| AUS	18
NCT03473756	Phase Ib/II	Atezolizumab Atezolizumab + Rogaratinib	Phase 1b/2 Study of Rogaratinib (BAY1163877) in Combination With Atezolizumab in Urothelial Carcinoma (FORT-2)	Active, not recruiting	USA \| ITA \| FRA \| ESP \| DEU \| AUT	2
NCT06263153	Phase II	Durvalumab + Futibatinib	Futibatinib in Combination With Durvalumab Prior to Cystectomy for the Treatment of Muscle-Invasive Bladder Cancer Patients Who Are Ineligible for Cisplatin-based Therapy	Not yet recruiting	USA	0
NCT03088059	Phase II	Niraparib Durvalumab + Monalizumab Methotrexate Carboplatin Rogaratinib Mitomycin C Docetaxel Afatinib Paclitaxel Durvalumab Monalizumab Palbociclib Bleomycin Gemcitabine Fluorouracil	Biomarker-based Study in R/M SCCHN (UPSTREAM)	Active, not recruiting	ITA \| GBR \| FRA \| ESP \| BEL	0
NCT04040725	Phase II	Rogaratinib	Rogaratinib for BCG Refractory High Risk Non-Muscle Invasive Bladder Cancer With FGFR1/2 Overexpression	Withdrawn		0
NCT03517956	Phase I	Copanlisib + Rogaratinib	Phase 1 Study of the Combination of Rogaratinib With Copanlisib in Patients With Fibroblast Growth Factor Receptor (FGFR)-Positive, Locally Advanced or Metastatic Solid Tumors (ROCOCO)	Completed	USA \| ESP \| DEU \| BEL	2
NCT02109016	Phase II	Lucitanib	A Study to Assess the Efficacy of the VEGFR-FGFR Inhibitor, Lucitanib, Given to Patients With FGFR1-driven Lung Cancer	Terminated	USA \| ITA \| FRA \| ESP \| DEU	0
NCT01868022	Phase I	Docetaxel Cisplatin + Pemetrexed Disodium GSK3052230 Carboplatin + Paclitaxel	Study to Evaluate GSK3052230 in Combination With Paclitaxel and Carboplatin, or Docetaxel or as Single Agent in Subjects With Solid Malignancies and Deregulated Fibroblast Growth Factor (FGF) Pathway Signaling	Completed	USA \| NLD \| GBR \| ESP \| BEL	2
NCT02202746	Phase II	Lucitanib	A Study to Assess the Safety and Efficacy of the VEGFR-FGFR Inhibitor, Lucitanib, Given to Patients With FGF Aberrant Metastatic Breast Cancer	Terminated	USA	0
NCT01004224	Phase I	Infigratinib	A Dose Escalation Study in Adult Patients With Advanced Solid Malignancies	Completed	USA \| NLD \| ITA \| FRA \| ESP \| DEU \| AUT \| AUS	6
NCT03344536	Phase Ib/II	Debio 1347 + Fulvestrant	A Study of Debio 1347 Plus Fulvestrant in Patients With Metastatic Breast Cancer	Completed	USA	0
NCT03238196	Phase I	Erdafitinib + Fulvestrant + Palbociclib	Fulvestrant, Palbociclib and Erdafitinib in ER+/HER2-/FGFR-amplified Metastatic Breast Cancer	Active, not recruiting	USA	0
NCT04092673	Phase Ib/II	Fulvestrant + Zotatifin Zotatifin Sotorasib + Zotatifin Abemaciclib + Fulvestrant + Zotatifin Trastuzumab + Zotatifin	Study of eFT226 in Subjects With Selected Advanced Solid Tumor Malignancies (Zotatifin)	Recruiting	USA	0
NCT04024436	Phase II	Fulvestrant + Futibatinib Futibatinib	A Study of TAS-120 in Patients With Metastatic Breast Cancer	Active, not recruiting	USA \| ITA \| GBR \| FRA \| ESP \| CAN	1
NCT02546661	Phase I	Danvatirsen + Durvalumab Durvalumab + Selumetinib AZD4547 Durvalumab + Olaparib Durvalumab AZD4547 + Durvalumab Durvalumab + Vistusertib Adavosertib + Durvalumab	Open-Label, Randomised, Multi-Drug, Biomarker-Directed, Phase 1b Study in Pts w/ Muscle Invasive Bladder Cancer (BISCAY)	Active, not recruiting	USA \| GBR \| FRA \| ESP \| CAN	0
NCT04601857	Phase II	Futibatinib + Pembrolizumab	Futibatinib and Pembrolizumab Combination in the Treatment of Advanced or Metastatic Urothelial Carcinoma	Active, not recruiting	USA \| FRA \| ESP	0
NCT03834220	Phase II	Debio 1347	Basket Trial in Solid Tumors Harboring a Fusion of FGFR1, FGFR2 or FGFR3- (FUZE Clinical Trial)	Terminated	USA \| NLD \| GBR \| FRA \| ESP \| AUT \| AUS	16
NCT03611868	Phase Ib/II	APG-115 + Pembrolizumab	A Study of APG-115 in Combination With Pembrolizumab in Patients With Metastatic Melanomas or Advanced Solid Tumors	Recruiting	USA \| AUS	0
NCT02268253	Phase II	Tagraxofusp-erzs	Tagraxofusp (SL-401) in Patients With CMML or MF	Completed	USA \| CAN	0
NCT03011372	Phase II	Pemigatinib	A Study to Evaluate the Efficacy and Safety of Pemigatinib (INCB054828) in Subjects With Myeloid/Lymphoid Neoplasms With FGFR1 Rearrangement - (FIGHT-203)	Active, not recruiting	USA \| ITA \| GBR \| FRA \| ESP \| DEU \| CAN \| BEL \| AUT	2
NCT04189445	Phase II	Futibatinib	Futibatinib in Patients With Specific FGFR Aberrations	Active, not recruiting	USA \| NLD \| ITA \| GBR \| FRA \| ESP \| DEU \| BEL	7
NCT03862157	Phase Ib/II	Azacitidine + MLN4924 + Venetoclax	Azacitidine, Venetoclax, and Pevonedistat in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia	Active, not recruiting	USA	0

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