Gene Detail

Gene Symbol TET2
Synonyms KIAA1546 | MDS
Gene Description TET2, methylcytosine dioxygenase TET2, is a member of the ten-eleven-translocation family of genes that plays a role in DNA methylation and is involved in hematopoesis (PMID: 26099018, PMID: 25510268, PMID: 27848178). TET2 has been identified as a tumor suppressor in hematological malignancies, and mutations in TET2 are common in hematological cancers including myelodysplastic syndrome, chronic myelomoncytic leukemia, and atypical CML (PMID: 26099018, PMID: 22240200, PMID: 30138727) and epigenetic dysregulation has been observed in glioblastoma (PMID: 29899831).
Entrez Id 54790
Chromosome 4
Map Location 4q24
Canonical Transcript NM_001127208

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Variant Impact Protein Effect Variant Description Associated with drug Resistance
D1242V missense loss of function - predicted TET2 D1242V does not lie within any known functional domains of the Tet2 protein (UniProt.org). D1242V is predicted to confer a loss of function on the Tet2 protein as demonstrated by the lack of WT1 binding and localization to WT1 target genes (PMID: 25601757).
L360W missense unknown TET2 L360W does not lie within any known functional domains of the Tet2 protein (UniProt.org). L360W has not been characterized in the scientific literature and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
G1256D missense loss of function - predicted TET2 G1256D does not lie within any known functional domains of the Tet2 protein (UniProt.org). G1256D is predicted to confer a loss of function on the Tet2 protein as demonstrated by the lack of WT1 binding and localization to WT1 target genes (PMID: 25601757).
H1382Y missense loss of function - predicted TET2 H1382Y lies within an iron binding catalytic residue of the Tet2 protein (UniProt.org). H1382Y has not been individually characterized but results in an enzymatically dead protein in conjunction with D1384A (PMID: 23222540) and the conserved position in mouse Tet2 is unable to convert 5mC to 5hmC (PMID: 21057493).
inact mut unknown loss of function TET2 inact mut indicates that this variant results in a loss of Tet2 protein function. However, the specific amino acid change has not been identified.
D1143fs frameshift loss of function - predicted TET2 D1143fs results in a change in the amino acid sequence of the Tet2 protein beginning at aa 1143 of 2002, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of the DNA-interacting region and substrate binding region (UniProt.org), D1143fs is predicted to lead to a loss of Tet2 function.
R1572Q missense unknown TET2 R1572Q does not lie within any known functional domains of the Tet2 protein (UniProt.org). R1572Q has not been characterized in the scientific literature and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
S1039L missense unknown TET2 S1039L does not lie within any known functional domains of the Tet2 protein (UniProt.org). S1039L has not been characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
Y1295A missense unknown TET2 Y1295A lies within the DNA interacting region of the Tet2 protein (UniProt.org). Y1295A has not been characterized individually however, results in a minor decrease in Tet2 enzymatic activity in conjunction with S1290A in a cell free assay (PMID: 24315485) and therefore, the effect on Tet2 protein function is unknown.
C1221Y missense unknown TET2 C1221Y does not lie within any known functional domains of the Tet2 protein (UniProt.org). C1221Y has been identified in sequencing studies (PMID: 24030381, PMID: 28481359), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
I1762V missense no effect TET2 I1762V does not lie within any known functional domains of the Tet2 protein (UniProt.org). I1762V has no effect on Tet2 protein function as demonstrated by the ability to produce amounts of 5hmC equivalent to Tet2 wild-type (J Cancer 2015; 6(9):832-842, (PMID: 26284134).
A1505T missense loss of function TET2 A1505T does not lie within any known functional domains of the Tet2 protein (UniProt.org). A1505T confers a loss of function to the Tet2 protein as demonstrated by the inability of A1505T to inhibit cell proliferation, lack of WT1 binding and regulation of WT1 target genes, and reduced enzymatic conversion of 5mC (PMID: 25601757).
K67fs frameshift loss of function - predicted TET2 K67fs results in a change in the amino acid sequence of the Tet2 protein beginning at aa 67 of 2002 (UniProt.org). Due to the loss of the catalytic domain (PMID: 25132561), K67fs is predicted to lead to a loss of Tet2 protein function.
Y1294A missense unknown TET2 Y1294A lies within the DNA interacting region of the Tet2 protein (UniProt.org). Y1294A has not been characterized individually however, results in a significant decrease in Tet2 enzymatic activity in conjunction with M1293A in a cell free assay (PMID: 24315485) and therefore, the effect on Tet2 protein function is unknown.
K1171fs frameshift loss of function - predicted TET2 K1171fs results in a change in the amino acid sequence of the Tet2 protein beginning at aa 1171 of 2002, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of the DNA-interacting region and substrate binding region (UniProt.org), K1171fs is predicted to lead to a loss of Tet2 function.
R1359C missense unknown TET2 R1359C does not lie within any known functional domains of the Tet2 protein (UniProt.org). R1359C has been identified in sequencing studies (PMID: 23365461), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
Q1524H missense unknown TET2 Q1524H does not lie within any known functional domains of the Tet2 protein (UniProt.org). Q1524H has not been characterized in the scientific literature and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
R1261G missense loss of function - predicted TET2 R1261G lies in a cysteine-rich region of the Tet2 protein (PMID: 24697267) and is a 2-oxoglutarate binding site (UniProt.org). R1261G is predicted to confer a loss of function to the Tet2 protein as demonstrated by the loss of Tet2 methylcytosine dioxygenase activity in cell based assays (PMID: 24697267).
D1427Y missense unknown TET2 D1427Y does not lie within any known functional domains of the TET2 protein (UniProt.org). D1427Y has been identified in sequencing studies (PMID: 21828143), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
Q876* nonsense loss of function - predicted TET2 Q876* results in a premature truncation of the Tet2 protein at amino acid 876 of 2002 (UniProt.org). Due to the loss of the DNA binding and substrate binding regions (UniProt.org), Q876* is predicted to lead to a loss of Tet2 protein function.
H1778R missense no effect - predicted TET2 H1778R does not lie within any known functional domains of the Tet2 protein (UniProt.org). H1778R is predicted to have no effect on Tet2 protein function as demonstrated by normal conversion levels of 5mC to 5hmC (PMID: 26284134).
C1273F missense unknown TET2 C1273F lies at a zinc binding site within the Tet2 protein (UniProt.org). C1273F has been identified in sequencing studies (PMID: 27276561), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
G355D missense unknown TET2 G355D does not lie within any known functional domains of the Tet2 protein (UniProt.org). G355D has been identified in sequencing studies (PMID: 27534895), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
L1514H missense unknown TET2 L1514H does not lie within any known functional domains of the Tet2 protein (UniProt.org). L1514H has not been characterized in the scientific literature and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
M1701I missense unknown TET2 M1701I does not lie within any known functional domains of the Tet2 protein (UniProt.org). M1701I has been identified in sequencing studies (PMID: 19420352), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
P1723S missense no effect - predicted TET2 P1723S does not lie within any known functional domains of the Tet2 protein (UniProt.org). P1723S is predicted to have no effect on Tet2 protein function as demonstrated by normal conversion levels of 5mC to 5hmC (PMID: 26284134).
A855S missense unknown TET2 A855S does not lie within any known functional domains of the Tet2 protein (UniProt.org). A855S has not been characterized in the scientific literature and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
H1380Y missense unknown TET2 H1380Y lies within a zinc coordination residue of the TET2 protein (UniProt.org). H1380Y has been identified in sequencing studies (PMID: 24030381, PMID: 21343549), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
P174H missense unknown TET2 P174H does not lie within any known functional domains of the Tet2 protein (UniProt.org). P174H has been identified in sequencing studies (PMID: 26415585), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
G1861R missense loss of function TET2 G1861R does not lie within any known functional domains of the Tet2 protein (UniProt.org). G1861R confers a loss of function to the Tet2 protein as demonstrated by the inability of G1861R to inhibit cell proliferation, lack of WT1 binding and regulation of WT1 target genes, and reduced enzymatic conversion of 5mC (PMID: 25601757).
R1302G missense loss of function - predicted TET2 R1302G lies within the DNA interacting region of the Tet2 protein (UniProt.org). R1302G is predicted to confer a loss of function on the Tet2 protein as demonstrated by the lack of WT1 binding and localization to WT1 target genes (PMID: 25601757).
S1303N missense unknown TET2 S1303N lies within the DNA interacting region of the Tet2 protein (UniProt.org). S1303N has not been characterized individually however, results in a loss of Tet2 enzymatic activity in conjunction with K1299E in a cell free assay (PMID: 24315485) and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
Q1540K missense unknown TET2 Q1540K does not lie within any known functional domains of the Tet2 protein (UniProt.org). Q1540K has not been characterized in the scientific literature and therefore, its effect on Tet2 function is unknown (PubMed, Aug 2018).
Q1084P missense unknown TET2 Q1084P does not lie within any known functional domains of the Tet2 protein (UniProt.org). Q1084P has been identified in sequencing studies (PMID: 19372255), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
S1290A missense unknown TET2 S1290A lies within the DNA interacting region of the Tet2 protein (UniProt.org). S1290A has not been characterized individually however, results in minor decrease of Tet2 enzymatic activity in conjunction with Y1295A in a cell free assay (PMID: 24315485) and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
W1291_N1296delinsGGSGGS deletion loss of function - predicted TET2 W1291_N1296delinsGGSGGS results in a deletion of six amino acids in the DNA interacting region of the Tet2 protein combined with the insertion of six new amino acids in the same location (UniProt.org). W1291_N1296delinsGGSGGS is predicted to confer a loss of function on the Tet2 protein as demonstrated by loss of enzymatic activity (PMID: 24315485).
H1219N missense unknown TET2 H1219N does not lie within any known functional domains of the TET2 protein (UniProt.org). H1219N has not been characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
P1889H missense unknown TET2 P1889H does not lie within any known functional domains of the TET2 protein (UniProt.org). P1889H has not been characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
H1868D missense unknown TET2 H1868D does not lie within any known functional domains of the Tet2 protein (UniProt.org). H1868D has not been characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
Y1902A missense unknown TET2 Y1902A lies within the substrate binding region of the Tet2 protein (UniProt.org). Y1902A has not been characterized individually however, results in decreased Tet2 enzymatic activity in conjunction with Y1295A in a cell free assay (PMID: 24315485) and therefore, the effect on Tet2 protein function is unknown.
wild-type none no effect Wild-type TET2 indicates that no mutations have been detected within the TET2 gene.
P1617H missense loss of function TET2 P1617H does not lie within any known functional domains of the Tet2 protein (UniProt.org). P1617H confers a loss of function to the Tet2 protein as demonstrated by the inability of P1617H to inhibit cell proliferation, lack of WT1 binding and regulation of WT1 target genes, and reduced enzymatic conversion of 5mC (PMID: 25601757).
C1378F missense unknown TET2 C1378F does not lie within any known functional domains of the Tet2 protein (UniProt.org). C1378F has been identified in sequencing studies (PMID: 28481359, PMID: 24413737), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
H1881R missense loss of function - predicted TET2 H1881R does not lie within any known functional domains of the Tet2 protein (UniProt.org). H1881R (corresponding to H1802R in the murine counterparts) results in decreased enzymatic activity of Tet2 in culture (PMID: 21057493).
R1359H missense unknown TET2 R1359H does not lie within any known functional domains of the Tet2 protein (UniProt.org). R1359H has been identified in sequencing studies (PMID: 24030381), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
S1607L missense unknown TET2 S1607L does not lie within any known functional domains of the Tet2 protein (UniProt.org). S1607L has not been characterized in the scientific literature and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
Y867H missense unknown TET2 Y867H does not lie within any known functional domains of the Tet2 protein (UniProt.org). Y867H has not been characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
M1293A missense unknown TET2 M1293A lies within the DNA interacting region of the Tet2 protein (UniProt.org). M1293A has not been characterized individually however, results in a loss of Tet2 enzymatic activity in conjunction with Y1294A in a cell free assay (PMID: 24315485) and therefore, the effect on Tet2 protein function is unknown.
N1387A missense loss of function - predicted TET2 N1387A does not lie within any known functional domains of the Tet2 protein (UniProt.org). N1387A is predicted to confer a loss of function to the Tet2 protein as demonstrated by decreased Tet2 enzymatic activity in a cell free assay (PMID: 24315485).
L34F missense unknown TET2 L34F does not lie within any known functional domains of the Tet2 protein (UniProt.org). L34F has been identified in sequencing studies (PMID: 23889083), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
R1896S missense loss of function - predicted TET2 R1896S lies in the catalytic double strand beta helix region of the Tet2 protein (PMID: 24697267) and in a binding region of 2-oxoglutarate (UniProt.org). R1896S is predicted to confer a loss of function on the Tet2 protein as demonstrated by substantial, but not total loss of Tet2 methylcytosine dioxygenase activity in cell based assays (PMID: 24697267).
W1291R missense loss of function TET2 W1291R lies within the DNA interacting region of the Tet2 protein (UniProt.org). W1291R results in a loss of Tet2 enzymatic activity in a cell free assay (PMID: 24315485) and the conserved position in mouse Tet2 is unable to convert 5mC to 5hmC (PMID: 21057493).
C1193W missense loss of function - predicted TET2 C1193W lies in a cysteine-rich region of the Tet2 protein (PMID: 24697267) and is at a metal binding residue (UniProt.org). C1193W is predicted to confer a loss of function to the Tet2 protein as demonstrated by the loss of Tet2 methylcytosine dioxygenase activity in cell based assays (PMID: 24697267).
T1884A missense loss of function - predicted TET2 T1884A does not lie within any known functional domains of the Tet2 protein (UniProt.org). T1884A is predicted to confer a loss of function on the Tet2 protein as demonstrated by the lack of WT1 binding and localization to WT1 target genes (PMID: 25601757).
L1721W missense no effect - predicted TET2 L1721W does not lie within any known functional domains of the Tet2 protein (UniProt.org). L1721W is predicted to have no effect on Tet2 protein function as demonstrated by normal conversion levels of 5mC to 5hmC (PMID: 26284134).
loss unknown loss of function TET2 loss indicates loss of the TET2 gene, mRNA, and protein.
Q1389* nonsense loss of function - predicted TET2 Q1389* results in a premature truncation of the Tet2 protein at amino acid 1389 of 2002 (UniProt.org). Due to the loss of the substrate binding domain (UniProt.org), Q1389* is predicted to result in a loss of Tet2 function.
D1384A missense loss of function - predicted TET2 D1384A lies within an iron binding catalytic residue of the Tet2 protein (UniProt.org). D1384A has not been individually characterized but results in an enzymatically dead protein in conjunction with H1382Y (PMID: 23222540) and the conserved position in mouse Tet2 is unable to convert 5mC to 5hmC (PMID: 21057493).
D1384V missense unknown TET2 D1384V lies within an iron binding catalytic residue of the Tet2 protein (UniProt.org). D1384V has not been individually characterized but results in an enzymatically dead protein in conjunction with H1382Y (PMID: 24315485) and therefore, the effect on Tet2 protein activity is unknown.
C1374Y missense unknown TET2 C1374Y does not lie within any known functional domains of the Tet2 protein (UniProt.org). C1374Y has been identified in sequencing studies (PMID: 24413737), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
G1275E missense unknown TET2 G1275E does not lie within any known functional domains of the Tet2 protein (UniProt.org). G1275E has been identified in sequencing studies (PMID: 20693430), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
V1718L missense unknown TET2 V1718L does not lie within any known functional domains of the Tet2 protein (UniProt.org). V1718L has been identified in sequencing studies (PMID: 24433485, PMID: 23781511), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
G1288S missense unknown TET2 G1288S does not lie within any known functional domains of the Tet2 protein (UniProt.org). G1288S has been identified in sequencing studies (PMID: 21828143, PMID: 26437031, PMID: 23832012), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
mutant unknown unknown TET2 mutant indicates an unspecified mutation in the TET2 gene.
R1896M missense loss of function - predicted TET2 R1896M does not lie within any known functional domains of the Tet2 protein (UniProt.org). R1896M is predicted to confer a loss of function on the Tet2 protein as demonstrated by reduced Tet2 enzyme activity (PMID: 24315485).
S1870L missense unknown TET2 S1870L does not lie within any known functional domains of the TET2 protein (UniProt.org). S1870L has been identified in sequencing studies (PMID: 24413737), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
H1380L unknown unknown TET2 H1380L lies within a zinc coordination residue of the TET2 protein (UniProt.org). H1380L has been identified in sequencing studies (PMID: 24345752, PMID: 29386642), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
I1873T missense loss of function - predicted TET2 I1873T lies in the catalytic double strand beta helix region of the Tet2 protein (PMID: 24697267). I1873T is predicted to confer a loss of function to the Tet2 protein as demonstrated by loss of Tet2 methylcytosine dioxygenase activity in cell based assays (PMID: 24697267).
H1904R missense loss of function - predicted TET2 H1904R lies within the substrate binding region of the Tet2 protein (UniProt.org). H1904R is predicted to confer a loss of function on the Tet2 protein as demonstrated by decreased Tet2 enzymatic activity in a cell-free assay (PMID: 24315485).
S358G missense unknown TET2 S358G does not lie within any known functional domains of the Tet2 protein (UniProt.org). S358G has been identified in sequencing studies (PMID: 24433485), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
R1262A missense loss of function - predicted TET2 R1262A does not lie within any known functional domains of the Tet2 protein (UniProt.org). R1262A is predicted to confer a loss of function to the Tet2 protein as demonstrated by a 2-4 fold decrease in enzymatic activity (PMID: 24315485).
H1881Q missense loss of function - predicted TET2 H1881Q does not lie within any known functional domains of the Tet2 protein (UniProt.org). H1881Q (corresponding to H1802Q in the murine counterparts) results in decreased enzymatic activity of Tet2 in culture (PMID: 21057493).
L1322P missense unknown TET2 L1322P does not lie within any known functional domains of the TET2 protein (UniProt.org). L1322P has been identified in sequencing studies (PMID: 24413737), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
H924R missense unknown TET2 H924R does not lie within any known functional domains of the Tet2 protein (UniProt.org). H924R has been identified in sequencing studies (PMID: 26984174), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
P363L missense no effect - predicted TET2 P363L does not lie within any known functional domains of the Tet2 protein (UniProt.org). P363L may have no effect on Tet2 protein function as demonstrated by normal conversion levels of 5mC to 5hmC (PMID: 26284134).
L1801F missense unknown TET2 L1801F does not lie within any known functional domains of the TET2 protein (UniProt.org). L1801F has been identified in sequencing studies (PMID: 21828143), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
P29R missense unknown TET2 P29R does not lie within any known functional domains of the Tet2 protein (UniProt.org). P29R has been identified in sequencing studies (PMID: 25589003), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
R2000I missense unknown TET2 R2000I does not lie within any known functional domains of the Tet2 protein (UniProt.org). R2000I has not been characterized in the scientific literature and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
I812fs frameshift loss of function - predicted TET2 I812fs results in a change in the amino acid sequence of the Tet2 protein beginning at aa 812 of 2002, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of the catalytic domain (PMID: 25132561), I812fs is predicted to lead to a loss of Tet2 protein function.
S1369* nonsense loss of function - predicted TET2 S1369* results in a premature truncation of the Tet2 protein at amino acid 1369 of 2002 (UniProt.org). Due to the loss of the substrate binding domain (UniProt.org), S1369* is predicted to result in a loss of function in the Tet2 protein.
L1326S missense unknown TET2 L1326S does not lie within any known functional domains of the TET2 protein (UniProt.org). L1326S has been identified in sequencing studies (PMID: 24850867), but has not been biochemically characterized and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
Q1624H missense unknown TET2 Q1624H does not lie within any known functional domains of the Tet2 protein (UniProt.org). Q1624H has not been characterized in the scientific literature and therefore, its effect on Tet2 protein function is unknown (PubMed, Aug 2018).
Molecular Profile Protein Effect Treatment Approaches
TET2 D1242V loss of function - predicted
TET2 L360W unknown
TET2 G1256D loss of function - predicted
TET2 H1382Y loss of function - predicted
TET2 inact mut TP53 wild-type
TET2 inact mut loss of function
TET2 D1143fs loss of function - predicted
TET2 R1572Q unknown
TET2 S1039L unknown
TET2 Y1295A unknown
TET2 C1221Y unknown
TET2 I1762V no effect
TET2 A1505T loss of function
TET2 K67fs loss of function - predicted
TET2 Y1294A unknown
TET2 K1171fs loss of function - predicted
TET2 R1359C unknown
TET2 Q1524H unknown
TET2 R1261G loss of function - predicted
TET2 D1427Y unknown
TET2 Q876* loss of function - predicted
TET2 H1778R no effect - predicted
TET2 C1273F unknown
TET2 G355D unknown
TET2 L1514H unknown
TET2 M1701I unknown
TET2 P1723S no effect - predicted
TET2 A855S unknown
TET2 H1380Y unknown
TET2 P174H unknown
TET2 G1861R loss of function
TET2 R1302G loss of function - predicted
TET2 S1303N unknown
TET2 Q1540K unknown
TET2 Q1084P unknown
TET2 S1290A unknown
TET2 W1291_N1296delinsGGSGGS loss of function - predicted
TET2 H1219N unknown
TET2 P1889H unknown
TET2 H1868D unknown
TET2 Y1902A unknown
TET2 wild-type no effect
TET2 P1617H loss of function
TET2 C1378F unknown
TET2 H1881R loss of function - predicted
TET2 R1359H unknown
TET2 S1607L unknown
TET2 Y867H unknown
TET2 M1293A unknown
TET2 N1387A loss of function - predicted
TET2 L34F unknown
TET2 R1896S loss of function - predicted
TET2 W1291R loss of function
TET2 C1193W loss of function - predicted
TET2 T1884A loss of function - predicted
TET2 L1721W no effect - predicted
TET2 loss TP53 wild-type
TET2 loss loss of function
TET2 Q1389* loss of function - predicted
TET2 D1384A loss of function - predicted
TET2 D1384V unknown
TET2 C1374Y unknown
TET2 G1275E unknown
TET2 V1718L unknown
TET2 G1288S unknown
ASXL1 wild-type TET2 mutant
TET2 mutant unknown
ASXL1 mut TET2 mut
TET2 R1896M loss of function - predicted
TET2 S1870L unknown
TET2 H1380L unknown
TET2 I1873T loss of function - predicted
TET2 H1904R loss of function - predicted
TET2 S358G unknown
TET2 R1262A loss of function - predicted
TET2 H1881Q loss of function - predicted
TET2 L1322P unknown
TET2 H924R unknown
TET2 P363L no effect - predicted
TET2 L1801F unknown
TET2 P29R unknown
TET2 R2000I unknown
TET2 I812fs loss of function - predicted
TET2 S1369* loss of function - predicted
TET2 L1326S unknown
TET2 Q1624H unknown
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ASXL1 wild-type TET2 mutant myelodysplastic/myeloproliferative neoplasm sensitive Azacitidine Clinical Study Actionable In a clinical study, myelodysplastic syndrome patients carrying TET2 mutations and wild-type ASXL1 demonstrated an increased response to treatment with the DNA hypomethylating agents Dacogen (decitabine) or Vidaza (azacitidine) compared to patients with other mutational profiles (65% vs. 44%; OR 2.37, P=0.49) (PMID: 25224413). 25224413
ASXL1 wild-type TET2 mutant myelodysplastic/myeloproliferative neoplasm sensitive Decitabine Clinical Study Actionable In a clinical study, myelodysplastic syndrome patients carrying TET2 mutations and wild-type ASXL1 demonstrated an increased response to treatment with the DNA hypomethylating agents Dacogen (decitabine) or Vidaza (azacitidine) compared to patients with other mutational profiles (65% vs. 44%; OR 2.37, P=0.49) (PMID: 25224413). 25224413
TET2 mutant acute myeloid leukemia not applicable N/A Clinical Study Prognostic In multiple clinical studies, including a meta-analysis, TET2 mutations were associated with shorter overall survival in patients with acute myeloid leukemia (PMID: 24524305, PMID: 25412851, PMID: 24994606). 24524305 25412851 24994606
TET2 mutant acute myeloid leukemia predicted - sensitive Azacitidine Phase I Actionable In a retrospective analysis, presence of a TET2 mutation correlated with higher overall response rate (ORR) in patients with myelodysplastic syndrome and acute myeloid leukemia following treatment with Vidaza (azacitidine), with an ORR of 85% (11/3) in TET2-mutated patients, compared to 47% (34/47) in patients with wild-type TET2, but did not correlate with overall survival (PMID: 21494260). 21494260