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Gene RET
Variant L790F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET L790F lies within the protein kinase domain of the Ret protein (UniProt.org). L790F results in ligand-independent phosphorylation of Ret (PMID: 15184865, PMID: 23526464), however, also results in similar cell proliferation and transformation activity to wild-type Ret in cell culture (PMID: 21810974, PMID: 32546069), and therefore, its effect on Ret protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RET mutant RET L790X RET L790F

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Transcript NM_020975.6
gDNA chr10:g.43118458G>T
cDNA c.2370G>T
Protein p.L790F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406759.1 chr10:g.43118458G>T c.2370G>T p.L790F RefSeq GRCh38/hg38
NM_020975 chr10:g.43118458G>T c.2370G>T p.L790F RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43118458G>T c.2370G>T p.L790F RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43118458G>T c.2370G>T p.L790F RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43118458G>T c.2370G>T p.L790F RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43118458G>T c.2370G>T p.L790F RefSeq GRCh38/hg38
NM_020630 chr10:g.43118458G>T c.2370G>T p.L790F RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43118458G>T c.2370G>T p.L790F RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43118458G>T c.2370G>T p.L790F RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43118458G>T c.2370G>T p.L790F RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET L790F Advanced Solid Tumor sensitive Ponatinib Preclinical Actionable In a preclinical study, Iclusig (ponatinib) inhibited phosphorylation of Ret in transformed human cells expressing RET L790F in culture (PMID: 23526464). 23526464
RET L790F Advanced Solid Tumor sensitive Vandetanib Preclinical Actionable In a preclinical study, Caprelsa (vandetanib) inhibited Ret autophosphorylation in transformed cells expressing RET L790F in culture (PMID: 15184865). 15184865