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|Protein Effect||no effect|
|Gene Variant Descriptions||BRAF amplification indicates an increased number of copies of the BRAF gene. However, the mechanism causing the increase is unspecified.|
|Associated Drug Resistance|
|Category Variants Paths|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|BRAF amp||lung non-small cell carcinoma||not predictive||unspecified immune checkpoint inhibitor||Clinical Study||Actionable||In a retrospective clinical study, no significant difference in overall survival (19.0 vs 18.4 months) was found in patients with non-small cell lung cancer harboring BRAF V600E (n=14), amplification (n=5), or non-V600E mutations (n=12) who received immunotherapy compared to those who never received immunotherapy (PMID: 31367539).||31367539|