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Gene FLT3
Variant A680V
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FLT3 A680V lies within the N-terminal kinase domain of the Flt3 protein (PMID: 15976757). A680V results in autophosphorylation of Flt3 (ASH, 2015, abstract no. 87) and leads to IL-3 independent growth in culture (PMID: 33563661).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 A680V

FLT3 mutant FLT3 exon16 FLT3 A680V

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Transcript NM_004119.3
gDNA chr13:g.28028192G>A
cDNA c.2039C>T
Protein p.A680V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119 chr13:g.28028192G>A c.2039C>T p.A680V RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28028192G>A c.2039C>T p.A680V RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28028192G>A c.2039C>T p.A680V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 A680V hematologic cancer sensitive Gilteritinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing FLT3 A680V were sensitive to treatment with Xospata (gilteritinib) in culture, demonstrating decreased cell viability and decreased Flt3 phosphorylation (PMID: 33563661). 33563661