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Gene FGFR2
Variant V565F
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR2 V565F (corresponds to V564F in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). V565F is predicted to confer a gain of function as demonstrated by increased Fgfr2 kinase activity in cell culture (PMID: 25169980), and has been shown to be associated with secondary resistance to FGFR inhibitors (PMID: 28034880, PMID: 31109923).
Associated Drug Resistance Y
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 V565F

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Transcript NM_001144913
gDNA chr10:g.121496705C>A
cDNA c.1693G>T
Protein p.V565F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144913 chr10:g.121496705C>A c.1693G>T p.V565F RefSeq GRCh38/hg38
XM_006717711 chr10:g.121488075_121488077delTACinsAAA c.1693_1695delGTAinsTTT p.V565F RefSeq GRCh38/hg38
XM_024447890.1 chr10:g.121488075_121488077delGTAinsTTT c.1693_1695delGTAinsTTT p.V565F RefSeq GRCh38/hg38
NM_022970 chr10:g.121496705C>A c.1693G>T p.V565F RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121496705C>A c.1693G>T p.V565F RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121496705C>A c.1693G>T p.V565F RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 V565F Advanced Solid Tumor predicted - sensitive TYRA-200 Preclinical Actionable In a preclinical study, TYRA-200 inhibited FGFR2 V565F in an in vitro assay, demonstrated activity in cells expressing FGFR2 V565F in culture, and induced 64% tumor growth regression in an allograft model (Eur J Cancer 2022 Vol 174, Supp 1:S16). detail...