Gene Variant Detail

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Gene FLT3
Variant D835Y
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FLT3 D835Y lies within the protein kinase domain activation loop of the Flt3 protein (UniProt.org, PMID: 11290608). D835Y results in constitutive phosphorylation of Flt3 and activation of Stat5, Erk signaling, leading to transformation of cultured cells (PMID: 15256420, PMID: 30651561), and has been demonstrated to promote secondary drug resistance in the context of FLT3 internal tandem duplication (FLT3-ITD) mutations (PMID: 22504184, PMID: 29187377).
Associated Drug Resistance Y
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 D835Y

FLT3 mutant FLT3 exon20 FLT3 D835X FLT3 D835Y

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Transcript NM_004119.2
gDNA chr13:g.28018505C>A
cDNA c.2503G>T
Protein p.D835Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28018505C>A c.2503G>T p.D835Y RefSeq GRCh38/hg38
NM_004119 chr13:g.28018505C>A c.2503G>T p.D835Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
FLT3 D835Y gain of function FLT3 Inhibitor
FLT3 exon 14 ins FLT3 D835Y
FLT3 exon 14 ins FLT3 F691L FLT3 D835Y
FLT3 N676D FLT3 D835Y
FLT3 F691L FLT3 D835Y
FLT3 D200N FLT3 D835Y
FLT3 L601F FLT3 D835Y
FLT3 D835Y IDH1 wild-type
FLT3 D835Y IDH1 R132H