Molecular Profile |
Indication/Tumor Type |
Response Type |
Relevant Treatment Approaches |
Therapy Name |
Approval Status |
Evidence Type |
Efficacy Evidence |
References |
FLT3 exon 14 ins FLT3 D835Y
|
acute myeloid leukemia
|
sensitive |
|
MRX-2843
|
Preclinical - Cell line xenograft |
Actionable |
In a preclinical study, MRX-2843 inhibited Flt3 signaling, resulted in growth inhibition in Quizartinib (AC220)-resistant acute myeloid leukemia cells harboring FLT3 internal tandem duplication (ITD) and D835Y in culture, and prolonged survival in cell line xenograft models (PMID: 27158668).
|
27158668
|
FLT3 exon 14 ins FLT3 D835Y
|
leukemia
|
resistant |
|
Pexidartinib
|
Clinical Study |
Actionable |
In a clinical study, a patient with FLT3-ITD positive leukemia initially responded to PLX3397 therapy, but experienced relapse after emergence of FLT3 D835Y on the same allele as the FLT3-ITD mutation (PMID: 25847190).
|
25847190
|
FLT3 exon 14 ins FLT3 D835Y
|
Advanced Solid Tumor
|
sensitive |
|
MRX-2843
|
Preclinical - Cell culture |
Actionable |
In a preclinical study, MRX-2843 inhibited Flt3 signaling, resulted in growth inhibition in Quizartinib (AC220)-resistant transformed cells over expressing both FLT3 internal tandem duplication (ITD) and D835Y in culture (PMID: 27158668).
|
27158668
|
FLT3 exon 14 ins FLT3 D835Y
|
Advanced Solid Tumor
|
resistant |
|
Pexidartinib
|
Preclinical |
Actionable |
In a preclinical study, FLT3 D835Y conferred resistance to PLX3397 when expressed in a compound mutation with FLT3-ITD in cell culture (PMID: 25847190).
|
25847190
|
FLT3 exon 14 ins FLT3 D835Y
|
Advanced Solid Tumor
|
sensitive |
|
Brigatinib
|
Preclinical - Cell culture |
Actionable |
In a preclinical study, Alunbrig (brigatinib) inhibited growth of transformed cells expressing FLT3 ITD and D835Y in culture (PMID: 27780853).
|
27780853
|
FLT3 exon 14 ins FLT3 D835Y
|
acute myeloid leukemia
|
sensitive |
|
FF-10101
|
Preclinical - Cell line xenograft |
Actionable |
In a preclinical study, FF-10101 inhibited Flt3 autophosphorylation and growth of leukemic cell lines and inhibited growth of cell line xenografts with FLT3-ITD/D835Y compound mutations (PMID: 29187377).
|
29187377
|