Therapy Detail
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| Therapy Name | HM43239 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| HM43239 | HM-43239|HM 43239 | FLT3 Inhibitor 54 | HM43239 inhibits both wild-type and mutant FLT3, resulting in decreased activation of downstream signaling, and potentially leading to increased apoptosis and decreased proliferation of tumor cells (Cancer Res 2019;79(13 Suppl):Abstract nr 1293). |
Filtering
- Case insensitive filtering will display rows where any text in any cell matches the filter term
- Simple literal full or partial string matches
- Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
- Use quotes to match a longer phrase which contains spaces "mtor c1483f"
Sorting
- Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FLT3 exon 14 ins FLT3 D835Y | hematologic cancer | predicted - sensitive | HM43239 | Preclinical | Actionable | In a preclinical study, HM43239 treatment inhibited transformed cells expressing FLT3 ITD and D835Y in cell culture (Cancer Res 2019;79(13 Suppl):Abstract nr 1293). | detail... |
| Unknown unknown | acute myeloid leukemia | not applicable | HM43239 | Preclinical - Cell culture | Actionable | In a preclinical study, HM43239 treatment inhibited downstream signaling, reduced proliferation, and induced apoptosis in an acute myeloid leukemia cell line expressing leukemic stem cell marker in culture (Cancer Res 2019;79(13 Suppl):Abstract nr 1293). | detail... |
| FLT3 exon 14 ins FLT3 F691L | hematologic cancer | predicted - sensitive | HM43239 | Preclinical | Actionable | In a preclinical study, HM43239 treatment inhibited transformed cells expressing FLT3 ITD and F691L in cell culture (Cancer Res 2019;79(13 Suppl):Abstract nr 1293). | detail... |
Filtering
- Case insensitive filtering will display rows where any text in any cell matches the filter term
- Simple literal full or partial string matches
- Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
- Use quotes to match a longer phrase which contains spaces "mtor c1483f"
Sorting
- Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status |
|---|---|---|---|---|
| NCT03850574 | Phase Ib/II | HM43239 | Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HM43239 in Patients With Relapsed or Refractory Acute Myeloid Leukemia | Recruiting |
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