Gene Variant Detail

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Gene FGFR1
Variant K687E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR1 K687E (corresponds to K656E in the canonical isoform) lies within the protein kinase domain of the Fgfr1 protein (UniProt.org). K687E has been identified in the scientific literature (PMID: 32622884, PMID: 34250399, PMID: 35952322), but has not been biochemically characterized and therefore, its effect on Fgfr1 protein function is unknown (PubMed, Mar 2024).
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 K687E

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Transcript NM_001174067.2
gDNA chr8:g.38414790T>C
cDNA c.2059A>G
Protein p.K687E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011544445.2 chr8:g.38414790T>C c.2059A>G p.K687E RefSeq GRCh38/hg38
XM_011544445.3 chr8:g.38414790T>C c.2059A>G p.K687E RefSeq GRCh38/hg38
XM_011544447.2 chr8:g.38414790T>C c.2059A>G p.K687E RefSeq GRCh38/hg38
XM_011544444.1 chr8:g.38414790T>C c.2059A>G p.K687E RefSeq GRCh38/hg38
XM_011544444.2 chr8:g.38414790T>C c.2059A>G p.K687E RefSeq GRCh38/hg38
NM_001174067.1 chr8:g.38414790T>C c.2059A>G p.K687E RefSeq GRCh38/hg38
XM_011544447.3 chr8:g.38414790T>C c.2059A>G p.K687E RefSeq GRCh38/hg38
NM_001174067.2 chr8:g.38414790T>C c.2059A>G p.K687E RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR1 M563I FGFR1 K687E oligodendroglioma predicted - sensitive Futibatinib Case Reports/Case Series Actionable In a Phase I trial (FOENIX-101), Lytgobi (futibatinib) treatment resulted in a partial response in a patient with anaplastic oligodendroglioma harboring FGFR1 M563I and FGFR1 K687E (PMID: 32622884; NCT02052778). 32622884
FGFR1 V592M FGFR1 K687E pilomyxoid astrocytoma predicted - sensitive Debio 1347 Case Reports/Case Series Actionable In a clinical case study, Debio 1347 treatment resulted in a significant clinical improvement and sustained stable disease at 14 months with a 12.2% maximal tumor reduction in a pediatric patient with optic pathway pilomyxoid astrocytoma harboring FGFR1 V592M and FGFR1 K687E (PMID: 34250399). 34250399
FGFR1 V592M FGFR1 K687E glioblastoma predicted - sensitive Debio 1347 Case Reports/Case Series Actionable In a clinical case study, Debio 1347 treatment resulted in a near complete response with a 96.3% maximal tumor reduction after 2 months of therapy in a pediatric patient with spinal cord glioblastoma harboring FGFR1 V592M and FGFR1 K687E, and the response was maintained for 11 months (PMID: 34250399). 34250399