Gene Variant Detail

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Gene BRAF
Variant G534D
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF G534D lies within the protein kinase domain of the Braf protein (UniProt.org). G534D has been demonstrated to confer resistance to Raf inhibitors in culture (PMID: 33953400), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Mar 2024).
Associated Drug Resistance Y
Category Variants Paths

BRAF mutant BRAF G534D

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Transcript NM_004333.6
gDNA chr7:g.140777005C>T
cDNA c.1601G>A
Protein p.G534D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354609.1 chr7:g.140777005C>T c.1601G>A p.G534D RefSeq GRCh38/hg38
XM_047420769.1 chr7:g.140777005C>T c.1601G>A p.G534D RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140777005C>T c.1601G>A p.G534D RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140777005C>T c.1601G>A p.G534D RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140777005C>T c.1601G>A p.G534D RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140777005C>T c.1601G>A p.G534D RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140777005C>T c.1601G>A p.G534D RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF G534D NRAS Q61L melanoma resistant Belvarafenib Preclinical - Cell culture Actionable In a preclinical study, expression of BRAF G534D in a melanoma cell line harboring NRAS Q61L conferred resistance to treatment with Belvarafenib (HM95573) in culture (PMID: 33953400). 33953400