Gene Variant Detail

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Gene FGFR2
Variant N549S
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FGFR2 N549S lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). N549S demonstrates increased transforming activity compared to wild-type Fgfr2 in culture (PMID: 34272467), and therefore, is predicted to lead to a gain of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 N549S

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Transcript NM_000141.5
gDNA chr10:g.121498521T>C
cDNA c.1646A>G
Protein p.N549S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_023029.2 chr10:g.121488064T>C c.1646A>G p.N549S RefSeq GRCh38/hg38
NM_001144915.2 chr10:g.121488064T>C c.1646A>G p.N549S RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121498521T>C c.1646A>G p.N549S RefSeq GRCh38/hg38
NM_001144919.2 chr10:g.121488067T>C c.1646A>G p.N549S RefSeq GRCh38/hg38
NM_001144915.1 chr10:g.121488064T>C c.1646A>G p.N549S RefSeq GRCh38/hg38
NM_001144919.1 chr10:g.121488067T>C c.1646A>G p.N549S RefSeq GRCh38/hg38
NM_023029.2 chr10:g.121488064T>C c.1646A>G p.N549S RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121498521T>C c.1646A>G p.N549S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 N549S Advanced Solid Tumor sensitive Infigratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 N549S were sensitive to treatment with Truseltiq (infigratinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 N549S Advanced Solid Tumor sensitive E7090 Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 N549S were sensitive to treatment with E7090 in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 N549S Advanced Solid Tumor sensitive Erdafitinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 N549S were sensitive to treatment with Balversa (erdafitinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 N549S Advanced Solid Tumor sensitive Futibatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 N549S were sensitive to treatment with Lytgobi (futibatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 N549S Advanced Solid Tumor sensitive Pemigatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 N549S were sensitive to treatment with Pemazyre (pemigatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 N549S Advanced Solid Tumor resistant Dovitinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 N549S were resistant to treatment with Dovitinib (TKI258) in culture (PMID: 34272467). 34272467