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Gene | ALK |
Variant | T1151R |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | ALK T1151R lies within the protein kinase domain of the Alk protein (UniProt.org). T1151R has been demonstrated to occur as a secondary drug resistance mutation in the context of ALK rearrangement (PMID: 31027750), but has not been biochemically characterized and therefore, its effect on Alk protein function is unknown (PubMed, Jan 2024). |
Associated Drug Resistance | Y |
Category Variants Paths |
ALK mutant ALK T1151R |
Transcript | NM_004304.5 |
gDNA | chr2:g.29222407G>C |
cDNA | c.3452C>G |
Protein | p.T1151R |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_004304.4 | chr2:g.29222407G>C | c.3452C>G | p.T1151R | RefSeq | GRCh38/hg38 |
NM_004304.5 | chr2:g.29222407G>C | c.3452C>G | p.T1151R | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ALK rearrange ALK T1151R | lung adenocarcinoma | predicted - resistant | Ceritinib | Case Reports/Case Series | Actionable | In a clinical case study, ALK T1151R was identified on post-progression biopsy in a patient with lung adenocarcinoma harboring an ALK rearrangement who had been on Zykadia (ceritinib) treatment for 6 months (PMID: 31027750). | 31027750 |
ALK rearrange ALK T1151R | lung adenocarcinoma | predicted - sensitive | Brigatinib | Case Reports/Case Series | Actionable | In a clinical case study, Alunbrig (brigatinib) treatment resulted in clinical improvement and a major response in tumor volume and metabolic activity in a patient with metastatic lung adenocarcinoma harboring an ALK rearrangement and ALK T1151R until disease progression 3 months later (PMID: 31027750). | 31027750 |