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Gene RAD51C
Variant Q133E
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions RAD51C Q133E lies within the Rad51b, Rad51d, and Xrcc3-interacting region of the Rad51c protein (UniProt.org). Q133E binds to Rad51d and supports cell proliferation to similar levels as wild-type Rad51c, but results in loss of interaction with Xrcc3, partial loss of interaction with Xrcc2, and reduced homology-directed DNA repair activity in culture (PMID: 37253112), and therefore, is predicted to lead to a loss of Rad51c protein function.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C inact mut RAD51C Q133E

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Transcript NM_058216.3
gDNA chr17:g.58695182C>G
cDNA c.397C>G
Protein p.Q133E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006722001.5 chr17:g.58695182C>G c.397C>G p.Q133E RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58695182C>G c.397C>G p.Q133E RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58695182C>G c.397C>G p.Q133E RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58695182C>G c.397C>G p.Q133E RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58695182C>G c.397C>G p.Q133E RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58695182C>G c.397C>G p.Q133E RefSeq GRCh38/hg38
NM_002876.4 chr17:g.58695182C>G c.397C>G p.Q133E RefSeq GRCh38/hg38
NM_002876.3 chr17:g.58695182C>G c.397C>G p.Q133E RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58695182C>G c.397C>G p.Q133E RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RAD51C Q133E Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C Q133E sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C Q133E Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C Q133E sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112