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Gene BRAF
Variant V600_W604delinsR
Impact List indel
Protein Effect unknown
Gene Variant Descriptions BRAF V600_W604delinsR results in the deletion of five amino acids in the protein kinase domain of the Braf protein from amino acids 600 to 604, combined with the insertion of an arginine (R) at the same site (UniProt.org). V600_W604delinsR has been identified in the scientific literature (PMID: 38766698, PMID: 30442523), but has not been biochemically characterized, and therefore, its effect on Braf protein function is unknown (PubMed, May 2024).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF V600_W604delinsR

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Transcript NM_004333.6
gDNA chr7:g.140753323_140753337delinsCCT
cDNA c.1798_1812delinsAGG
Protein p.V600_W604delinsR
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333.6 chr7:g.140753323_140753337delinsCCT c.1798_1812delinsAGG p.V600_W604delinsR RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753323_140753337delinsCCT c.1798_1812delinsAGG p.V600_W604delinsR RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753323_140753337delinsCCT c.1798_1812delinsAGG p.V600_W604delinsR RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753323_140753337delinsCCT c.1798_1812delinsAGG p.V600_W604delinsR RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600_W604delinsR lung adenocarcinoma predicted - sensitive Dabrafenib + Trametinib Case Reports/Case Series Actionable In a clinical case study, treatment with the combination of Tafinlar (dabrafenib) and Mekinist (trametinib) resulted in a partial response after 48 days, shrinkage of metastatic lesions, and decreased pleural effusion in a patient with advanced lung adenocarcinoma harboring BRAF V600_W604delinsR (PMID: 38766698). 38766698