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|Protein Effect||no effect|
|Gene Variant Descriptions||Wild-type KIT indicates that no mutation has been detected within the KIT gene.|
|Associated Drug Resistance|
|Category Variants Paths|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|KIT wild-type||acute myeloid leukemia||sensitive||BPR1J373||Preclinical - Cell culture||Actionable||In a preclinical study, an acute myeloid leukemia cell line harboring KIT wild-type was sensitive to BPR1J373 in culture, demonstrating apoptotic induction and inhibition of cell proliferation (PMID: 27512117).||27512117|
|KIT wild-type||acute megakaryocytic leukemia||decreased response||Avapritinib||Preclinical - Cell culture||Actionable||In a preclinical study, KIT wild-type megakaryocytic leukemia cells were less sensitive to Ayvakit (avapritinib) compared to cells harboring KIT mutations in culture (PMID: 29093181).||29093181|
|KIT wild-type||Advanced Solid Tumor||sensitive||PLX9486||Preclinical - Cell culture||Actionable||In a preclinical study, PLX9486 treatment inhibited proliferation of ligand-stimulated cells expressing wild-type KIT in culture (PMID: 30523507).||30523507|