Disease Detail


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ID DOID:8761
Name megakaryocytic leukemia
Definition A leukemia that derives from blood-forming tissue in which megakaryocytes proliferate in the bone marrow and circulate in the blood in large numbers.
Source DiseaseOntology.org
Alt Ids DOID:9009
Path disease disease of cellular proliferation cancer organ system cancer hematologic cancer leukemia megakaryocytic leukemia


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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
GATA1 over exp Cytarabine megakaryocytic leukemia decreased response detail...
GATA1 over exp Daunorubicin megakaryocytic leukemia decreased response detail...
GATA1 mutant N/A megakaryocytic leukemia not applicable detail...
KIT wild-type Avapritinib megakaryocytic leukemia decreased response detail...
JAK2 V617F Ropeginterferon megakaryocytic leukemia sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT02530619 Phase I Alisertib Alisertib in Treating Patients With Myelofibrosis or Relapsed or Refractory Acute Megakaryoblastic Leukemia Unknown status