Molecular Profile Detail

Profile Name TP53 E258Q
Gene Variant Detail

TP53 E258Q (loss of function)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 E258Q osteosarcoma resistant Nutlin-3 Preclinical Actionable In a preclinical study, TP53 E258Q resulted in secondary resistance in an osteosarcoma cell line acquired during Nutlin-3 treatment (PMID: 21643018). 21643018
Clinical Trial Phase Therapies Title Recruitment Status