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Profile Name | NTRK2 R734C |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
NTRK2 R734C | Advanced Solid Tumor | resistant | AZD6918 | Preclinical | Actionable | In a preclinical study, a transformed cell line expressing NTRK2 R734C was resistant to inhibition of Ntrk2 autophosphorylation and BDNF-induced cell proliferation by AZD6918 treatment in culture (PMID: 21242122). | 21242122 |