Molecular Profile Detail

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Profile Name NRAS amp
Gene Variant Detail

NRAS amp (no effect)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
NRAS amp melanoma predicted - sensitive Binimetinib Preclinical - Pdx Actionable In a preclinical study, Mektovi (binimetinib) treatment resulted in reduced tumor growth and proliferation in two patient-derived xenograft (PDX) melanoma models with NRAS copy number gain and without BRAF or NRAS mutations (PMID: 29245078). 29245078
Clinical Trial Phase Therapies Title Recruitment Status
NCT03992456 Phase II Panitumumab Regorafenib trifluridine/tipiracil hydrochloride Panitumumab, Regorafenib, or TAS-102, in Treating Patients With Metastatic and/or Unresectable RAS Wild-Type Colorectal Cancer Recruiting