Molecular Profile Detail

Profile Name FLT3 exon 14 ins FLT3 F691L FLT3 Y842C
Gene Variant Detail

FLT3 exon 14 ins (gain of function - predicted)

FLT3 F691L (no effect - predicted)

FLT3 Y842C (gain of function)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 exon 14 ins FLT3 F691L FLT3 Y842C Advanced Solid Tumor resistant Pexidartinib Preclinical Actionable In a preclinical study, transformed cells expressing a compound FLT3-ITD/F691L/Y842C mutation were resistant to PLX3397 in culture (PMID: 25847190). 25847190
Clinical Trial Phase Therapies Title Recruitment Status