Molecular Profile Detail

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Profile Name FLT3 exon 14 ins FLT3 F691L FLT3 D835G
Gene Variant Detail

FLT3 D835G (gain of function - predicted)

FLT3 exon 14 ins (gain of function - predicted)

FLT3 F691L (no effect - predicted)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 exon 14 ins FLT3 F691L FLT3 D835G Advanced Solid Tumor resistant Pexidartinib Preclinical Actionable In a preclinical study, transformed cells expressing a compound FLT3-ITD/F691L/D835G mutation were resistant to PLX3397 in culture (PMID: 25847190). 25847190