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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|RAD51D loss||Advanced Solid Tumor||sensitive||Olaparib||Olaparib||Preclinical||Actionable||In a preclinical study, cells harboring biallelic loss-of-function mutations in RAD51D had increased sensitivity to Lynparza (olaparib) compared to cells with wild-type RAD51D (PMID: 21822267).||21822267|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT03840967||Phase II||Niraparib||A Study Evaluating Safety and Efficacy of Niraparib in Patients With Previously Treated Metastatic Esophageal/Gastroesophageal Junction/Proximal Gastric Adenocarcinoma||Recruiting||USA||0|
|NCT05174455||Phase II||Niraparib||Niraparib for the Treatment of Leiomyosarcoma||Not yet recruiting||USA||0|