Molecular Profile Detail


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Profile Name ALK F1245V
Gene Variant Detail

ALK F1245V (gain of function)

Relevant Treatment Approaches ALK Inhibitor


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK F1245V neuroblastoma predicted - sensitive ALK Inhibitor Entrectinib Case Reports/Case Series Actionable In a combined analysis of 2 Phase I trials (ALKA-372-001, STARTRK-1), Rozlytrek (entrectinib) treatment resulted in a partial response that lasted 8.3 months in a patient with neuroblastoma harboring ALK F1245V, who remained on treatment for over 3.5 years due to clinical benefit (PMID: 28183697; NCT02097810). 28183697
ALK F1245V neuroblastoma predicted - sensitive ALK Inhibitor Lorlatinib Case Reports/Case Series Actionable In a Phase I trial, Lorbrena (lorlatinib) treatment resulted in a complete response of marrow disease in a neuroblastoma patient harboring ALK F1245V, along with NF1 P2472fs and BRCA2 F2410fs (PMID: 37147298; NCT03107988). 37147298