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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|JAK3 L156P||Advanced Solid Tumor||sensitive||JAK Inhibitor (Pan) - ATP competitive||Tofacitinib||Preclinical - Cell culture||Actionable||In a preclinical study, transformed human cells expressing JAK3 L156P in culture demonstrated decreased cell survival, increased G1 arrest, and reduced phosphorylation of Stat5a when treated with Xeljanz (tofacitinib) (PMID: 21821710).||21821710|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|