Molecular Profile Detail


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Profile Name ALK F1174V
Gene Variant Detail

ALK F1174V (gain of function - predicted)

Relevant Treatment Approaches ALK Inhibitor


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK F1174V neuroblastoma sensitive ALK Inhibitor Brigatinib Preclinical - Cell culture Actionable In a preclinical study, neuroblastoma cells harboring ALK F1174V were sensitive to Alunbrig (brigatinib) in culture and in vivo, resulting in inhibition of both Alk activity and cell proliferation (PMID: 27049722). 27049722
ALK F1174V neuroblastoma predicted - sensitive ALK Inhibitor Crizotinib Case Reports/Case Series Actionable In a Phase I/II trial (ADVL0912), Xalkori (crizotinib) treatment resulted in an objective response of 15% (3/20) in pediatric patients with relapsed/refractory neuroblastoma harboring ALK activating mutations or amplifications, a patient harboring ALK F1174V stayed on treatment for 3 cycles until disease progression (PMID: 33568345; NCT00939770). 33568345
ALK F1174V neuroblastoma predicted - resistant ALK Inhibitor Repotrectinib Preclinical - Pdx Actionable In a preclinical study, a neuroblastoma patient-derived xenograft (PDX) model harboring ALK F1174V was resistant to treatment with Repotrectinib (TPX-0005) (PMID: 34482287). 34482287
ALK F1174V neuroblastoma predicted - sensitive ALK Inhibitor Irinotecan + Repotrectinib + Temozolomide Preclinical - Pdx Actionable In a preclinical study, combination treatment with Repotrectinib (TPX-0005), Camptosar (irinotecan), and Temodar (temozolomide) resulted in inhibition of tumor growth in a patient-derived xenograft (PDX) model of neuroblastoma harboring ALK F1174V (PMID: 34482287). 34482287