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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|PIK3CA E545K PIK3CA amp||lung squamous cell carcinoma||predicted - sensitive||Buparlisib||Preclinical - Cell line xenograft||Actionable||In a preclinical study, Buparlisib (BKM120) treatment resulted in inhibition of AKT and S6 phosphorylation and durable responses in 2 of 3 lung squamous cell carcinoma patient-derived xenograft (PDX) models harboring PIK3CA E545K and PIK3CA amplification (PMID: 30093452).||30093452|
|PIK3CA E545K PIK3CA amp||cervical cancer||sensitive||Copanlisib + Neratinib||Preclinical - Cell line xenograft||Actionable||In a preclinical study, the combination of Aliqopa (copanlisib) and Nerlynx (neratinib) synergistically inhibited viability of a cervical cancer cell line harboring PIK3CA E545K with PIK3CA amplification in culture and inhibited tumor growth and increased survival in a cell line xenograft model (PMID: 31624127).||31624127|