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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FLT3 D835H||hematologic cancer||predicted - sensitive||FLT3 Inhibitor||HQP1351||Preclinical - Cell culture||Actionable||In a preclinical study, transformed cells expressing FLT3 D835H demonstrated decreased proliferation in response to GZD824 (HQP1351) in culture, but were less sensitive to treatment than cells expressing other FLT3 kinase domain mutations (PMID: 32247263).||32247263|
|FLT3 D835H||acute myeloid leukemia||sensitive||FLT3 Inhibitor||Crenolanib||Preclinical||Actionable||In a preclinical study, Crenolanib (CP-868596) inhibited Flt3 phosphorylation and induced apoptosis in leukemia cells expressing FLT3 D835H (PMID: 24623852).||24623852|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|