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|Profile Name||KIT E554_K558del|
|Gene Variant Detail|
|Relevant Treatment Approaches||KIT Inhibitor|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|KIT E554_K558del||gastrointestinal stromal tumor||predicted - sensitive||KIT Inhibitor||Binimetinib + Imatinib||Case Reports/Case Series||Actionable||In a Phase II trial, Gleevec (imatinib) and Mektovi (binimetinib) combination treatment had manageable toxicity and resulted in a 99% pathological response and 29% RECIST response in a patient with a rectal gastrointestinal stromal tumor harboring KIT E554_K558del (PMID: 35041493; NCT01991379).||35041493|