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|Profile Name||APC T1556Nfs*3|
|Gene Variant Detail|
|Relevant Treatment Approaches||CTNNB1 Inhibitor Tankyrase Inhibitor|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|APC T1556Nfs*3||desmoid tumor||predicted - sensitive||Celecoxib + Nirogacestat||Case Reports/Case Series||Actionable||In a clinical case study, addition of Nirogacestat (PF-03084014) to Celecoxib treatment resulted in a reduction in tumor size and stable disease that was ongoing for at least 17 months in a pediatric patient with a desmoid tumor harboring APC T1556Nfs*3 (PMID: 32762028).||32762028|