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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
CTNNB1 S45F Imatinib desmoid tumor sensitive detail...
CTNNB1 act mut Imatinib desmoid tumor sensitive detail...
CTNNB1 T41A Imatinib desmoid tumor sensitive detail...
CTNNB1 mutant N/A desmoid tumor not applicable detail...
APC mutant N/A desmoid tumor not applicable detail...
CTNNB1 T41A BMS-906024 desmoid tumor predicted - sensitive detail...
APC inact mut BMS-906024 desmoid tumor predicted - sensitive detail...
APC T1556Nfs*3 Celecoxib + Nirogacestat desmoid tumor predicted - sensitive detail...
APC inact mut Nirogacestat desmoid tumor predicted - sensitive detail...
APC R1450* APC LOH Nirogacestat desmoid tumor predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03264664 Phase I E7386 Study of E7386 in Participants With Selected Advanced Neoplasms Recruiting USA | GBR 0
NCT03422679 Phase Ib/II CB-103 Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and Haematological Malignancies Terminated USA | FRA | ESP | DEU 2
NCT03459469 Phase I BC2059 Phase I, Open-label, Non-randomized Study to Evaluate Safety of BC2059 Completed USA | CAN 0
NCT03785964 Phase III Nirogacestat Nirogacestat for Adults With Desmoid Tumor/Aggressive Fibromatosis (DT/AF) (DeFi) Active, not recruiting USA | NLD | ITA | GBR | DEU | CAN | BEL 0
NCT03886311 Phase II Nivolumab + Talimogene laherparepvec + Trabectedin Talimogene Laherparepvec, Nivolumab and Trabectedin for Sarcoma (TNT) Recruiting USA 0
NCT04195399 Phase II Nirogacestat A Study of a New Drug, Nirogacestat, for Treating Desmoid Tumors That Cannot be Removed by Surgery Active, not recruiting USA | NZL | CAN | AUS 1
NCT04851119 Phase Ib/II BC2059 Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors Recruiting USA 0
NCT04871282 Phase II AL102 A Study of AL102 in Patients With Progressing Desmoid Tumors (RINGSIDE) Active, not recruiting USA | NLD | ITA | GBR | ESP | DEU | BEL | AUS 3
NCT05879146 Phase II Nirogacestat Evaluation of the Response and Non-response of Nirogacestat in Desmoid Tumors- Clinical Study Not yet recruiting USA 0
NCT05949099 Phase II Nirogacestat Study of Cryoablation and Nirogacestat for Desmoid Tumor Recruiting USA 0