Therapy Detail

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Therapy Name BMS-906024
Synonyms
Therapy Description

BMS-906024 is a pan-NOTCH inhibitor, which may limit growth and survival of cancer cells (PMID: 28978720).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
BMS-906024 AL 101|AL101|AL-101 NOTCH Inhibitor (Pan) 5 BMS-906024 is a pan-NOTCH inhibitor, which may limit growth and survival of cancer cells (PMID: 28978720).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
APC inact mut desmoid tumor predicted - sensitive BMS-906024 Case Reports/Case Series Actionable In a clinical case study, BMS-906024 treatment resulted in a partial response that lasted for at least 2.6 years in a patient with a desmoid tumor harboring an inactivating APC mutation (PMID: 34590610). 34590610
CTNNB1 T41A desmoid tumor predicted - sensitive BMS-906024 Case Reports/Case Series Actionable In a Phase I trial, BMS-906024 treatment resulted in a partial response that lasted for 3.6 years on treatment and at least another 4 years after the end of treatment in a patient with a desmoid tumor harboring CTNNB1 T41A (PMID: 34590610; NCT01292655). 34590610

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04973683 Phase I BMS-906024 AL101 Before Surgery for the Treatment of Notch Activated Adenoid Cystic Cancer Recruiting USA 0
NCT04461600 Phase II BMS-906024 A Study of AL101 Monotherapy in Patients With Notch Activated Triple Negative Breast Cancer (TENACITY) Active, not recruiting USA | GBR | ESP | BEL 1
NCT03691207 Phase II BMS-906024 A Study Of AL101 In Patients With Adenoid Cystic Carcinoma (ACC) Bearing Activating Notch Mutations (ACCURACY) Unknown status USA | GBR | FRA | CAN 2
NCT01292655 Phase I BMS-906024 Study to Evaluate the Safety and Tolerability of IV Doses of BMS-906024 in Subjects With Advanced or Metastatic Solid Tumors Completed USA | CAN | AUS 0
NCT01363817 Phase I Dexamethasone BMS-906024 Study to Evaluate the Safety and Tolerability of Weekly Intravenous (IV) Doses of BMS-906024 in Subjects With Acute T-cell Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma Completed USA | FRA | DEU 0
NCT01653470 Phase I Carboplatin Fluorouracil + Irinotecan + Leucovorin BMS-906024 Paclitaxel Study to Evaluate Safety & Tolerability of BMS-906024 in Combination With Chemotherapy & to Define DLTs & MTD of BMS-906024 in Combination With One of the Following Chemotherapy Regimens; Weekly Paclitaxel, 5FU+Irinotecan or Carboplatin+Paclitaxel in Subjects With Advanced / Metastatic Solid Tumors Completed USA | CAN | BEL 0


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