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|Profile Name||MAP2K1 P124L|
|Gene Variant Detail|
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|MAP2K1 P124L||melanoma||resistant||Selumetinib||Preclinical||Actionable||In a preclinical study, transformed human melanoma cells expressing MAP2K1 P124L demonstrated resistance to the MEK inhibitor, Selumetinib (AZD6244) (PMID: 19915144).||19915144|
|MAP2K1 P124L||lymphatic system cancer||predicted - sensitive||Cobimetinib||Case Reports/Case Series||Actionable||In a Phase II trial, treatment with Cotellic (cobimetinib) in patients with histiocytic neoplasms resulted in a PET overall response rate of 89% (16/18), with complete response in 72% (13/18) and partial response in 17% (3/18), and resulted in stable disease in 6% (1/18) of patients, including a complete response in a patient with mixed histiocytosis harboring MAP2K1 P124L (PMID: 30867592; NCT01953926).||30867592|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|