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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|BRIP1 Q554Hfs*35||endometrial serous adenocarcinoma||predicted - sensitive||Olaparib||Olaparib||Case Reports/Case Series||Actionable||In a clinical case study, Lynparza (olaparib) treatment resulted in rapid clinical improvement and an ongoing complete response 9 months after initiation of treatment in a patient with high-grade serous endometrial carcinoma harboring a BRIP1 Q554Hfs*35 mutation, who also harbored other genomic changes consistent with homologous recombination defects including loss of heterozygosity in BRCA2, MAP3K1, PIK3R1, PTCH1, and KDM6A (PMID: 32923896).||32923896|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|