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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|TP53 R175L||colorectal cancer||sensitive||p53 Activator||NSC59984||Preclinical - Cell culture||Actionable||In a preclinical study, treatment with NSC59984 resulted in increased degradation of mutant Tp53 and cell death in a colorectal cancer cell line harboring TP53 R175L in culture (PMID: 26294215).||26294215|
|TP53 R175L||lung large cell carcinoma||sensitive||p53 Activator||NSC319726||Preclinical - Cell culture||Actionable||In a preclinical study, lung large cell carcinoma cells harboring TP53 R175L demonstrated increased sensitivity to NSC319726 in culture (PMID: 22624712).||22624712|