Molecular Profile Detail


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Profile Name TP53 R175L
Gene Variant Detail

TP53 R175L (loss of function)

Relevant Treatment Approaches p53 Activator p53 Gene Therapy


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 R175L colorectal cancer sensitive p53 Activator NSC59984 Preclinical - Cell culture Actionable In a preclinical study, treatment with NSC59984 resulted in increased degradation of mutant Tp53 and cell death in a colorectal cancer cell line harboring TP53 R175L in culture (PMID: 26294215). 26294215
TP53 R175L lung large cell carcinoma sensitive p53 Activator NSC319726 Preclinical - Cell culture Actionable In a preclinical study, lung large cell carcinoma cells harboring TP53 R175L demonstrated increased sensitivity to NSC319726 in culture (PMID: 22624712). 22624712