Molecular Profile Detail


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Profile Name BRAF class 3
Gene Variant Detail

BRAF class 3 (loss of function)

Relevant Treatment Approaches


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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06007924 Phase II Defactinib + RO5126766 A Study of Avutometinib and Defactinib in People With Thyroid Cancer Recruiting USA 0
NCT04913285 Phase I Binimetinib + Exarafenib Exarafenib A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors Recruiting USA | FRA | ESP | AUS 4
NCT05512208 Phase II Defactinib + RO5126766 A Phase 2 Study of Avutometinib (VS-6766) Plus Defactinib Recruiting USA 0
NCT05355701 Phase I Binimetinib + PF-07799933 PF-07799933 Cetuximab + PF-07799933 A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors. Recruiting USA | CAN 1
NCT04589845 Phase II Alectinib Ado-trastuzumab emtansine Ipatasertib Inavolisib Entrectinib Atezolizumab Idasanutlin Tumor-Agnostic Precision Immuno-Oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study Recruiting USA | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUS 15
NCT05786924 Phase I BDTX-4933 A Study of BDTX-4933 in Patients With BRAF and Select RAS/MAPK Mutation-Positive Cancers Recruiting USA 0
NCT04418661 Phase Ib/II Pembrolizumab + RMC-4630 Adagrasib + RMC-4630 Safety and Efficacy Study of SAR442720 in Combination With Other Agents in Advanced Malignancies Active, not recruiting USA | ESP | AUS 6
NCT05580770 Phase Ib/II BGB3245 + PD-0325901 Mirdametinib + BGB-3245 in Advanced Solid Tumors Recruiting USA | AUS 0