Molecular Profile Detail

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Profile Name BRAF V600E CDKN2A loss NRAS G12V
Gene Variant Detail

BRAF V600E (gain of function)

CDKN2A loss (loss of function)

NRAS G12V (loss of function)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E CDKN2A loss NRAS G12V melanoma predicted - sensitive Palbociclib + Ulixertinib Preclinical - Pdx Actionable In a preclinical study, combination treatment with Ibrance (palbociclib) and Ulixertinib (BVD-523) led to inhibition of tumor growth in a patient-derived xenograft (PDX) model of melanoma harboring BRAF V600E, NRAS G12V and a loss of copy number in CDKN2A (PMID: 34376578). 34376578
BRAF V600E CDKN2A loss NRAS G12V melanoma predicted - sensitive Palbociclib + Trametinib Preclinical - Pdx Actionable In a preclinical study, combination treatment with Ibrance (palbociclib) and Mekinist (trametinib) led to inhibition of tumor growth in a patient-derived xenograft (PDX) model of melanoma harboring BRAF V600E, NRAS G12V and a loss of copy number in CDKN2A (PMID: 34376578). 34376578
BRAF V600E CDKN2A loss NRAS G12V melanoma predicted - resistant Cobimetinib + Vemurafenib Case Reports/Case Series Actionable In a clinical case study, a melanoma patient harboring BRAF V600E experienced progressive disease after 10 months of combination therapy with Zelboraf (vemurafenib) and Cotellic (cobimetinib), likely due to the acquisition of NRAS G12V and a loss of one copy of CDKN2A (PMID: 34376578). 34376578
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries