Molecular Profile Detail


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Profile Name FLT3 exon 14 ins FLT3 N676K
Gene Variant Detail

FLT3 exon 14 ins (gain of function - predicted)

FLT3 N676K (gain of function)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 exon 14 ins FLT3 N676K acute myeloid leukemia predicted - resistant Midostaurin Case Reports/Case Series Actionable In a clinical case study, a patient with acute myeloid leukemia harboring a FLT3-ITD mutation progressed on Rydapt (midostaurin) after 288 days and was found to have acquired a FLT3 N676K mutation, and resistance was also confirmed in patient-derived cells in culture (PMID: 16150941). 16150941
FLT3 exon 14 ins FLT3 N676K acute myeloid leukemia predicted - resistant Pexidartinib Case Reports/Case Series Actionable In a Phase I/II trial, an acute myeloid leukemia patient harboring a FLT3-ITD was found to have acquired FLT3 N676K following relapse on Turalio (pexidartinib) treatment (PMID: 34103301; NCT01349049). 34103301
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries