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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FLT3 exon 14 ins FLT3 D698N FLT3 D835V||hematologic cancer||predicted - resistant||FF-10101||Preclinical - Cell culture||Actionable||In a preclinical study, transformed hematologic cells expressing FLT3-ITD with FLT3 D698N and D835V were moderately resistant to treatment with FF-10101 in culture (PMID: 35395091).||35395091|
|FLT3 exon 14 ins FLT3 D698N FLT3 D835V||hematologic cancer||resistant||Gilteritinib||Preclinical - Cell culture||Actionable||In a preclinical study, transformed cells expressing FLT3 ITD with FLT3 D835V and FLT3 D698N were resistant to Xospata (gilteritinib) in culture (PMID: 32040554).||32040554|