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|Profile Name||ATM Q1970*|
|Gene Variant Detail|
|Relevant Treatment Approaches||Olaparib|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ATM Q1970*||breast ductal carcinoma||predicted - sensitive||PLX038 + Rucaparib||Case Reports/Case Series||Actionable||In a clinical trial, PLX038 and Rubraca (rucaparib) combination treatment resulted in a complete response within the first treatment cycle, followed by PLX038 monotherapy, which resulted in maintenance of tumor suppression for a total of 12 months in a patient with metastatic breast ductal carcinoma harboring germline ATM Q1970* (PMID: 35999657; NCT04209595).||35999657|