Molecular Profile Detail


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Profile Name ATM Q1970*
Gene Variant Detail

ATM Q1970* (loss of function - predicted)

Relevant Treatment Approaches Olaparib


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM Q1970* breast ductal carcinoma predicted - sensitive PLX038 + Rucaparib Case Reports/Case Series Actionable In a clinical trial, PLX038 and Rubraca (rucaparib) combination treatment resulted in a complete response within the first treatment cycle, followed by PLX038 monotherapy, which resulted in maintenance of tumor suppression for a total of 12 months in a patient with metastatic breast ductal carcinoma harboring germline ATM Q1970* (PMID: 35999657; NCT04209595). 35999657