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|Therapy Name||PLX038 + Rucaparib|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|PLX038||PLX038A|PLX-038|PLX 038||TOPO Inhibitor (Pan) 3||PLX038 is a PEG-conjugated form of the topoisomerase inhibitor SN-38 (PMID: 31707444).|
|Rucaparib||Rubraca||AG014699|PF-01367338|CO-388|AG14447||PARP Inhibitor (Pan) 26||Rubraca (rucaparib) binds to and inhibits PARP, which may result in accumulation of DNA damage and chemosensitization of tumor cells (PMID: 17363489). Rubraca (rucaparib) is FDA approved for use as a maintenance therapy in patients with platinum-sensitive recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer, for treatment in patients with epithelial ovarian, fallopian tube, or primary peritoneal cancer harboring deleterious somatic and/or germline BRCA mutations who received 2 or more chemotherapies, and in patients with a deleterious BRCA mutation (germline and/or somatic)-associated metastatic castration-resistant prostate cancer who received anti-androgen therapy and a taxane-based therapy (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04209595||Phase Ib/II||PLX038 + Rucaparib||PLX038 (PEGylated SN38) and Rucaparib in Solid Tumors and Small Cell Cancers||Recruiting||USA||0|